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In addition, knockdown of NNT increased cellular and mitochondrial NADH/total NAD(H) in human SK-Hep1 cells under basal and ADP-stimulated conditions compared with control shRNA-transfected cells, whereas cellular and mitochondrial NADPH/total NADP(H) was much lower in NNT-silenced cells, which correlated with an increase in mitochondrial ROS generation (33)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 181.Marceau F., Bawolak M.T., Lodge R., Bouthillier J., Gagne-Henley A., Gaudreault R.C., Morissette G